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Level 202

Substitution & Elimination Reactions

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Neutral/Neg. Nucleophile
1st degree substrate SN2
1st degree substrate E2
Big bulky base that is too bulky for SN2 such as T-but or LDA
Small strong base
2nd degree substrate SN2
Big bulky base
2nd degree substrate E2
Only polar protic solvent
2nd degree substrate SN1 and E1
Strong Base
_______ dissociate completely into metal ions and hydroxide ion in aqueous solutions.
3rd degree substrate SN1 and E1
This is necessary for E2 reactions