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Chemotherapy agents


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cyclophosphamide
Example of an alkylating agent that leads to cross-linking of DNA
methotrexate
Anti-folic acid drug that leads to competitive inhibition of DNA synthesis
cisplatin
Example of a platinum compound that leads to cross-linking of DNA
daunorubicin
Example of an anti-tumour antibiotic that interferes with DNA & RNA synthesis
vincristine
Example of an anti-microtubule drug that inhibits spindle assembly, blocking cell division
paclitaxel
Example of an anti-microtubule drug that prevents microtubule breakdown after cell division
rituximab
Anti-CD20 monoclonal antibody used in B-cell non Hodgkin lymphomas
trastuzumab
Anti-Her2 receptor monoclonal antibody used in ~25% of breast cancers
Mabthera
Trade name for rituximab
Herceptin
Trade name for trastuzumab
imatinib
Drug that inhibits the abnormal tyrosine kinase in CML
chlorambucil
Oral alkylating agent used in the treatment of CLL
fludarabine
Purine that leads to competitive inhibition of DNA synthesis and is used in the treatment of CLL