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Immunophenotyping & genotyping


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CD5
Antigen normally expressed on T-cells that is also expressed on malignant B-cells in CLL
CD19
Antigen present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts
CD20
Antigen present on B cells from late pro-B cells through to memory cells (but not on blasts)
t(9;22)
Most common chromosomal abnormality in CML, known as the Philadelphia chromosome
t(15;17)
Most common chromosomal abnormality in acute promyelocytic leukaemia
t(14;18)
Most common chromosomal abnormality in indolent NHL
t(11;14)
Most common chromosomal abnormality in mantle cell lymphoma
t(8;14)
Most common chromosomal abnormality in Burkitt's lymphoma
bcr-abl
Fusion gene that is overexpressed in CML
pml-rarα
Fusion gene that is overexpressed in acute promyelocytic leukaemia
bcl-2
Gene that is overexpressed in indolent NHL
bcl-1
Gene that is overexpressed in mantle cell lymphoma
c-myc
Gene that is overexpressed in Burkitt's lymphoma