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Haemostasis


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haemostasis
Physiological response to blood vessel damage that stops bleeding and maintains the circulation
endothelin
Vasoconstrictor released by damaged blood vessel
von Willebrand factor
Mediates platelet adhesion, and is the carrier protein for Factor VIII
integrins
Membrane proteins on activated platelets that bind fibrinogen irreversibly
thromboxane A2, ADP
Two substances released by activated platelets that recruit more platelets
haemostatic plug
A plug of degranulated platelets & fibrin mesh (plus leukocytes & entrapped RBCs)
zymogen
Circulating, inactive form of a clotting factor
thrombin
Factor IIa in the coagulation cascade, which converts fibrinogen to fibrin and activates XIII
fibrinogen
Inactive form of fibrin
fibrin
Monomer which self-assembles to a polymer to produce a clot
XIII
The final factor in the coagulation cascade, which crosslinks the fibrin polymer to form an insoluble clot
tissue factor, VII
The factors in the extrinsic pathway of the classical coagulation cascade
VIII, IX, XI, XII
The factors in the intrinsic pathway of the classical coagulation cascade
II, V, X, XIII
The factors in the common pathway of the classical coagulation cascade
VIIa
The only factor that circulates in an active form
tenase complex
Complex formed by factors VIIIa & IXa
prothrombinase complex
Complex formed by factors Va & Xa
thrombosis
Pathological occlusion of blood vessels
protein C
Thrombin triggers the anti-thrombotic pathway via this protein
plasmin
Protein that lyses clots
plasminogen
Inactive form of plasmin
fibrinolysis
The process of breaking down clots