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Module VIII - Blood


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plasmapheresis
blood returned with plasma removed
gamma globulins
immune functions (antibodies)
120 days
lifespan of red blood cell
erythropoeitin
hormone from kidneys stimulates bone marrow to produce RBCs
hematocrit
percent of RBC in blood, normal 40%-45%
leukocytes
white blood cells, immune function
granulocytes
neutrophils, eosinophils, basophils
agranulocytes
monocytes and lymphocytes
neutrophils
phagocytosis (50%-60%)
eosinophils
kill parasites, allergic rxns (2%-3%)
basophils
hypersensitivity/secrete heparin and histamine (1%)
monocytes
destroy large particles/phagocytosis (3%)
lymphocytes
immune function (25%)
platelets
thrombocytes/clotting(10 day lifespan)
Type A
A antigen, B antibodies
Type B
B antigen, A antibodies
Type AB
A and B antigens, no antibodies, universal recipient
Type O
no antigens, antibodies for A and B, universal donor
Rh factor
rhesus factor (antigen)
erythroblastosis fetalis
Rh neg mother has antibodies against Rh from first Rh positive baby, 2nd Rh positive baby's RBCs destroyed. Treatment with Rhogam.
aglutination
clumping of blood cells and particles
thromb
blood clot
ESR
erythrocyte sedimentation rate/indicative of inflammation,tissue injury
MCH
mean corpuscular hemoglobin (average density of hemoglobin in RBCs)/ classification of anemia
PT
prothrombin time/tests for coagulation defects
PTT
partial thromboplastin time/tests for coagulation defects
dyscrasia
disease of the blood with abnormal material present
fibrinogen
protein in plasma forms clots
thrombocytopenia
lack of platelets/bleeding disorder
Idiopathic Thrombocytopenic Purpura
ITP
pancytopenia
low number of all blood cells
hemochromatosis
iron build up
poikilocytosis
irregularly shaped blood cells
reticulocytosis
irregular immature red blood cells
polycythemia
increase in red blood cells
leukemia
disorder with excessive increase of white blood cells
granulocytosis
abnormal increase in granulocytes during infection
multiple myeloma
malignant bone marrow tumor/increases WBC
albumin
plasma protein
serum
liquid of blood without clotting factor
anisocytosis
abnormal variation in rbc sizes
hemostatic
stop bleeding/ex: aminocaproic acid, recombinant facotr VIIa, Vitamin K (clotting agent)
anticoagulant
prevents formation of blood clots/ex: heparin, enoxaparin(Lovenox), dipyramidole
Von Willebrand's Disease
hemorrhagic disorder with tendency to bleed from mucous mebranes/lack of Factor VIIII
megakaryocyte
large cells in bone marrow that form platelets
prothrombin
plasma protein that aids in clotting
CBC
complete blood count
blood chemistry
tests plasma for substances such as glucose, cholesterol, uric acid, and electrolytes
platelet count
number of thrombocytes in blood
hemoglobin (Hgb)
level of hemoglobin in blood
iron-deficiency anemia
low iron levels affect the production of hemoglobin
aplastic anemia
failure of bone marrow to produce enough red blood cells
pernicious anemia
shape and number of RBCs change due to malabsorption of vitamin B12
hemolytic anemia
disorder of destruction of RBCs
thalassemia
inherited disorder (Mediterranean origin)/inability to produce sufficient hemoglobin
hemochromatosis
hereditary disorder/excessive buildup of iron/leads to heart failure
polycythemia
disease causing abnormal increase in RBC